Thursday, 12 July 2018

Statins do cause Diabetes: latest evidence



Followers of this blog would be well informed on our views on the link between statins and diabetes. We think that there is a considerable risk and therefore, we are seeking ways to reduce inflammation and not cholesterol.
Our latest review on this topic is this one:
Inflammation, not Cholesterol, Is a Cause of Chronic Disease

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An interesting and very recent review paper on associating statins and diabetes is this one
The Association of Statin Therapy with Incident Diabetes: Evidence, Mechanisms, and Recommendations.

The authors write:
Recent studies have demonstrated a higher risk of incident diabetes associated with statin use, causing concern among patients and clinicians. In this review, we will assess the evidence and proposed mechanisms behind statin therapy and its association with incident diabetes. We will then review the current recommendations for statin use in light of this association and suggest next steps for clinicians managing these patients and researchers exploring this phenomenon.

RECENT FINDINGS:

The annual risk of developing new-onset diabetes with statin treatment is approximately 0.1%. In comparison, the absolute risk reduction of major coronary events with statin use is approximately 0.42% annually. Statins are associated with the development of incident diabetes, particularly among those with predisposing risk factors for diabetes. However, the benefit of statin use among these patients in preventing major coronary events strongly favors statin use despite its risk of incident diabetes.

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In order to calculate risks (like 0.1 and 0.4 above), it is crucial to study all the relevant data.
Our data, to be published in our  book
“The Impact of Nutrition and Statins on Cardiovascular Diseases”
suggest that we need to have a completely different approach.

More to follow very soon.

Ioannis
 

 
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