Communication
In Vitro Anti‐Atherogenic Properties of N‐Heterocyclic Carbene Aurate(I) Compounds
Kristof vanhecke
First published: 01 November 2018
Abstract
The anti‐atherogenic (anti‐inflammatory) properties of various
aurate(I) salts, of the general formula [NHC·H][AuCl2] (NHC =
N‐heterocyclic carbene) have been investigated. The aurates are easily
synthesized and obtained in analytically pure form. In addition, the
biological activity of these compounds against atheromatosis via in
vitro inhibition of platelet‐activating factor (PAF) induced platelet
aggregation was probed. All complexes were found to possess
anti‐aggregatory properties in vitro with [IPr*·H][AuCl2] 6 being the
most potent inhibitor of PAF in micromolar concentration. Based on our
findings, we conclude that these simply assembled aurates are a very
promising class of PAF‐inhibitors and anti‐inflammatory drugs.
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In this paper, we have collaborated with the team of Prof S.P. Nolan in Gent to study the antithrombotic properties of Au-complexes.
Special thanks are due to my ex-PhD-student and now a post-doctoral researcher in Gent, Dr Eleni Sioriki!
[Good things do happen eventually, my Dear Eleni! #Believe! Yours, Ioannis]
Ioannis Zabetakis
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In this paper, we have collaborated with the team of Prof S.P. Nolan in Gent to study the antithrombotic properties of Au-complexes.
Special thanks are due to my ex-PhD-student and now a post-doctoral researcher in Gent, Dr Eleni Sioriki!
[Good things do happen eventually, my Dear Eleni! #Believe! Yours, Ioannis]
Ioannis Zabetakis
