*This is the first systematic review of cohortstudies where low-density lipoprotein cholesterol(LDL-C) has been analysed as a risk factor forall-cause and/or cardiovascular mortality inelderly people.
▪Lack of an association or an inverse associationbetween LDL-C and mortality was present in allstudies.
▪We may not have included studies where an evaluation of LDL-C as a risk factor for mortality was performed but where it was not mentioned in the title or in the abstract.
▪We may have overlooked relevant studies because we have only searched PubMed.
▪Minor errors may be present because some of the authors may not have adjusted LDL-C by appropriate risk factors.
▪Some of the participants with high LDL-C may have started statin treatment during the observation period and, in this way, may have added a longer life to the group with high LDL-C and some of them may have started with a diet able to influence the risk of mortality.
▪We may have overlooked a small number of relevant studies because we only searched papers in English.
the full paper is here